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Lorazepam - Drug Details

Lorazepam (Ativan)

Classification
Benzodiazepine
Mechanism of Action
Indications
Anxiety disorders, sedation, status epilepticus
Dosage and Administration
1-3 mg orally two to three times daily
Forms
Tablets, injection
Side Effects
Drowsiness, dizziness, weakness
Contraindications
Severe respiratory insufficiency, acute narrow-angle glaucoma
Interactions
Avoid alcohol and other CNS depressants
Precautions
Use caution in elderly patients and those with a history of substance abuse
Pharmacokinetics
Half-life: 12 hours, metabolized in the liver
Pharmacodynamics
Potentiates the inhibitory effects of GABA
Storage Requirements
Store at room temperature
Patient Counselling
Counsel on potential sedation and avoid driving or operating heavy machinery
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