Sertraline - Drug Details

Sertraline (Zoloft)

Classification

Selective serotonin reuptake inhibitor (SSRI)

Mechanism of Action

Indications

Depression, anxiety disorders, PTSD

Dosage and Administration

50-200 mg orally once daily

Forms

Tablets, oral solution

Side Effects

Nausea, insomnia, sexual dysfunction

Contraindications

Concurrent use with MAO inhibitors

Interactions

May increase bleeding risk with NSAIDs or anticoagulants

Precautions

Monitor for worsening depression or suicidal thoughts

Pharmacokinetics

Half-life: 26 hours, extensively metabolized in the liver

Pharmacodynamics

Increases serotonin levels in the brain

Storage Requirements

Store at room temperature

Patient Counselling

Take as prescribed, may take several weeks to see improvement

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