Atorvastatin - Drug Details

Atorvastatin (Lipitor)

Classification

HMG-CoA reductase inhibitor (statin)

Mechanism of Action

Indications

Hypercholesterolemia, cardiovascular disease prevention

Dosage and Administration

10-80 mg orally once daily

Forms

Tablets

Side Effects

Myopathy, diarrhea, nausea

Contraindications

Active liver disease, pregnancy, breastfeeding

Interactions

May increase the effects of warfarin

Precautions

Monitor liver enzymes and muscle symptoms regularly

Pharmacokinetics

Half-life: 14 hours, active metabolites have a half-life of 20-30 hours

Pharmacodynamics

Lowers cholesterol levels by reducing its synthesis

Storage Requirements

Store at room temperature, protect from light

Patient Counselling

Avoid large quantities of grapefruit juice, monitor for muscle pain

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