Losartan - Drug Details

Losartan (Cozaar)

Classification

Angiotensin II receptor blocker (ARB)

Mechanism of Action

Indications

Hypertension, diabetic nephropathy, stroke prevention

Dosage and Administration

25-100 mg orally once daily

Forms

Tablets

Side Effects

Dizziness, hyperkalemia, hypotension

Contraindications

Pregnancy, severe renal impairment

Interactions

May increase serum potassium with potassium supplements

Precautions

Monitor blood pressure and renal function regularly

Pharmacokinetics

Half-life: 2 hours, active metabolite has a half-life of 6-9 hours

Pharmacodynamics

Reduces blood pressure by blocking the effects of angiotensin II

Storage Requirements

Store at room temperature, protect from moisture

Patient Counselling

Counsel on potential dizziness on standing, avoid potassium-rich foods

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