Esomeprazole - Drug Details

Esomeprazole (Nexium)

Classification

Proton pump inhibitor

Mechanism of Action

Indications

GERD, peptic ulcer disease, Zollinger-Ellison syndrome

Dosage and Administration

20-40 mg orally once daily

Forms

Capsules, tablets, injection

Side Effects

Headache, diarrhea, abdominal pain

Contraindications

Hypersensitivity to other PPIs

Interactions

May reduce the absorption of drugs dependent on gastric pH

Precautions

Use the lowest effective dose for the shortest duration

Pharmacokinetics

Half-life: 1-1.5 hours, metabolized in the liver

Pharmacodynamics

Inhibits the final step of acid production in the stomach

Storage Requirements

Store at room temperature, protect from light

Patient Counselling

Take at least 1 hour before meals, do not crush or chew the capsules

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