Rosuvastatin - Drug Details

Rosuvastatin (Crestor)

Classification

HMG-CoA reductase inhibitor (statin)

Mechanism of Action

Indications

Hypercholesterolemia, cardiovascular disease prevention

Dosage and Administration

5-40 mg orally once daily

Forms

Tablets

Side Effects

Myopathy, abdominal pain, nausea

Contraindications

Active liver disease, pregnancy, breastfeeding

Interactions

May increase INR in patients on warfarin

Precautions

Monitor liver enzymes before and during treatment

Pharmacokinetics

Half-life: 19 hours, primarily excreted in the feces

Pharmacodynamics

Reduces total cholesterol, LDL-C, and triglycerides, increases HDL-C

Storage Requirements

Store at room temperature, protect from moisture

Patient Counselling

Avoid grapefruit juice, monitor for muscle pain or weakness

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