Metformin - Drug Details

Metformin (Glucophage, Fortamet)

Classification

Biguanide

Mechanism of Action

Indications

Type 2 diabetes

Dosage and Administration

500-1000 mg orally twice daily

Forms

Tablets, extended-release tablets

Side Effects

Diarrhea, nausea, lactic acidosis

Contraindications

Severe renal impairment, metabolic acidosis

Interactions

May interact with alcohol to increase risk of lactic acidosis

Precautions

Monitor renal function regularly

Pharmacokinetics

Half-life: 6.2 hours, excreted unchanged in urine

Pharmacodynamics

Reduces hepatic gluconeogenesis and increases peripheral glucose uptake

Storage Requirements

Store at room temperature, protect from moisture

Patient Counselling

Take with food to reduce gastrointestinal side effects

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