Donepezil - Drug Details

Donepezil (Aricept)

Classification

Acetylcholinesterase inhibitor

Mechanism of Action

Indications

Alzheimer's disease

Dosage and Administration

5-10 mg orally once daily at bedtime

Forms

Tablets

Side Effects

Nausea, insomnia, muscle cramps

Contraindications

Bradycardia, hypersensitivity

Interactions

Caution with other cholinergic drugs

Precautions

Monitor for gastrointestinal bleeding in high-risk patients

Pharmacokinetics

Half-life: 70 hours, metabolized in the liver

Pharmacodynamics

Enhances cholinergic function in the CNS

Storage Requirements

Store at room temperature

Patient Counselling

Counsel on taking the medication at bedtime to reduce nausea

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