Spironolactone - Drug Details

Spironolactone (Aldactone)

Classification

Potassium-sparing diuretic, aldosterone antagonist

Mechanism of Action

Indications

Heart failure, hypertension, hyperaldosteronism

Dosage and Administration

25-100 mg orally once daily

Forms

Tablets

Side Effects

Hyperkalemia, gynecomastia, menstrual irregularities

Contraindications

Hyperkalemia, Addison's disease

Interactions

May increase serum potassium with ACE inhibitors

Precautions

Monitor electrolytes regularly, use caution in renal impairment

Pharmacokinetics

Half-life: 1.4 hours, active metabolites have longer half-lives

Pharmacodynamics

Inhibits the effects of aldosterone on the distal tubules

Storage Requirements

Store at room temperature, protect from light and moisture

Patient Counselling

Monitor blood pressure and potassium levels regularly

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