Duloxetine - Drug Details

Duloxetine (Cymbalta)

Classification

Serotonin-Norepinephrine Reuptake Inhibitor (SNRI)

Mechanism of Action

Indications

Depression, anxiety, neuropathic pain

Dosage and Administration

30-60 mg once daily

Forms

Capsule

Side Effects

Nausea, dry mouth, fatigue, dizziness

Contraindications

Concurrent use with MAO inhibitors

Interactions

Increased risk of serotonin syndrome with other serotonergic agents

Precautions

Monitor for worsening depression or suicidal thoughts

Pharmacokinetics

Absorbed in the intestines, metabolized in the liver, excreted in urine

Pharmacodynamics

Improves mood and reduces pain perception

Storage Requirements

Store at room temperature, protect from light and moisture

Patient Counselling

Swallow the capsule whole, do not chew or crush

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