Sertraline - Drug Details

Sertraline (Zoloft)

Classification

Selective Serotonin Reuptake Inhibitor (SSRI)

Mechanism of Action

Indications

Depression, anxiety, OCD, PTSD

Dosage and Administration

50-200 mg once daily

Forms

Tablet, oral solution

Side Effects

Nausea, insomnia, dry mouth, sexual dysfunction

Contraindications

Concurrent use with MAO inhibitors or pimozide

Interactions

Increased risk of serotonin syndrome with other serotonergic agents

Precautions

Monitor for worsening depression or suicidal thoughts, particularly in young adults

Pharmacokinetics

Absorbed orally, metabolized in the liver, excreted in urine and feces

Pharmacodynamics

Improves mood by increasing serotonin levels in the brain

Storage Requirements

Store at room temperature, away from light

Patient Counselling

Take with or without food, preferably in the morning

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